ABOUT US
關(guān)于我們
董事長 黃文林
chairman Huang Wenlin
董事長寄語
CHAIRMAN MESSAGE
基因治療藥物是在人類基因組學(xué)及疾病基因組學(xué)的基礎(chǔ)上創新能力,九十年代發(fā)展起來的一種新興的治療技術(shù)及藥物綠色化,是精準(zhǔn)醫(yī)學(xué)的重要組成部分強大的功能。其原理是利用人體的正辰Y論;蛱娲蛔兓虺聊幕颍赃_(dá)到治療單基因或多基因變異引起的疾病迎難而上,包括糖尿病積極,心血管疾病、腫瘤生產創效、兒童罕見病等結構。在通向精準(zhǔn)醫(yī)療的路上,有美好的愿景橫向協同,任重而道遠(yuǎn)哪些領域,還需要我們不斷吸取新技術(shù)敢於挑戰,進(jìn)行產(chǎn)學(xué)研的有效整合不斷創新,為市場提供高品質(zhì)的生物醫(yī)療產(chǎn)品建立和完善。目前公司正在研究進(jìn)行中的項目,包括針對腫瘤抗新生血管生成參與水平、腫瘤轉(zhuǎn)錄點(diǎn)大型、免疫再平衡及細(xì)胞周期色素放療保護(hù)等產(chǎn)品,形成以腫瘤生產(chǎn)的關(guān)鍵微環(huán)境為靶點(diǎn)的新藥研發(fā)系列產(chǎn)品明確相關要求。
我僅代表達(dá)博生物制品有限公司全體員工,共同祝愿人類的健康保障走向新紀(jì)元推進一步,讓我們的生活更加豐富多彩經過!
董事長介紹
CHAIRMAN INTRODUCED
黃文林教授,公司董事長力度,腫瘤學(xué)家明確了方向,國務(wù)院特殊津貼專家,國家高層次人才勇探新路,國家新藥評審中心審評專家單產提升,科技部973傳染病領(lǐng)域咨詢專家,中國生物醫(yī)藥協(xié)會基因治療學(xué)會副會長方法,中山大學(xué)腫瘤防治中心教授行動力,香港中文大學(xué)名譽(yù)教授,廣州市創(chuàng)新創(chuàng)業(yè)領(lǐng)軍人才切實把製度。
1988年至2001年在美國學(xué)習(xí)深造保供,2001年回國任中山大學(xué)腫瘤防治中心教授,是中山大學(xué)基因治療奠基人之一銘記囑托。申請中國引領、美國及國際發(fā)明專利24項,研究轉(zhuǎn)化的國家1類新藥重組人內(nèi)皮抑素腺病毒(E10A)注射液已進(jìn)入Ⅲ期臨床試驗(批件號:2012L02744)示範。在Nat Med應用前景、PNAS、JCI運行好、JVI首次、JI、Mol Ther、Biomaterials搖籃、等國際著名SCI刊物發(fā)表論文100余篇技術。主編全國研究生教材《分子病毒學(xué)》、《信號傳導(dǎo)》推動、《腫瘤分子靶向治療》相對較高、《黑色素瘤》等。曾先后獲得教育部十大優(yōu)秀留學(xué)人員稱號信息、第十二屆中國發(fā)明專利國家金獎相關、國家科學(xué)技術(shù)進(jìn)步獎、教育部自然科學(xué)一等獎豐富內涵,中華醫(yī)學(xué)獎一等獎和廣東省科學(xué)技術(shù)獎一等獎等生產效率。
榮譽(yù)證書
Certificate Of Honor
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
榮譽(yù)證書
出版的代表性著作
AUTHORIZED INVENTION PATENT
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黃文林(主編):
全國研究生教材《分子病毒學(xué)》(第三版),人民衛(wèi)生出版社適應性,2016保持穩定。
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黃文林(主編):
《腫瘤分子靶向治療》,人民衛(wèi)生出版社面向,2009
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黃文林支撐作用、朱孝峰(主編):
《信號轉(zhuǎn)導(dǎo)與疾病》(第2版) ,人民衛(wèi)生出版社建設項目,2012最為突出。
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黃文林(主編):
《個體化醫(yī)學(xué)原則》 ,人民衛(wèi)生出版社相結合,2013高效化。
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張曉實,陳映波為產業發展,黃文林(主編):
《黑色素瘤基礎(chǔ)與臨床》範圍和領域,人民衛(wèi)生出版社,2010高效利用。
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麥海強(qiáng)特征更加明顯、黃文林(主編):
《生物制藥有神跡——基因藥物的誕生與發(fā)展》,廣東科技出版社講理論,2011的可能性。
所發(fā)文章列表
THE POST LIST
1. Liu T, Wu X, Li Y, Lu W, Zheng F, Zhang C, Long Q, Qiu H, Li Y, Ge Q, Chen M, Yu X, Chen W, Zhang H, Huang W, Luo M, Deng W, Li L. RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways. Cell Physiol Biochem. 2018 Apr 18;46(4):1365-1380.
2. Shuai W, Wu J, Chen S, Liu R, Ye Z, Kuang C, Fu X, Wang G, Li Y, Peng Q, Shi W, Li Y, Zhou Q, Huang W. SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter. Cancer Lett. 2018 May 28;422:56-69.
3. Li Y, Ye Z, Chen S, Pan Z, Zhou Q, Li YZ, Shuai WD, Kuang CM, Peng QH, Shi W, Mao X, Liu RY, Huang W. ARHGEF19 interacts with BRAF to activate MAPK signaling during the tumorigenesis of non-small cell lung cancer. Int J Cancer. 2018 Apr 1;142(7):1379-1391.
4. Ye W, Ling S, Liu RY, Pan ZZ, Wang G, Gao S, Wu J, Cao L, Dong L, Li Y, ZhouY, Du W, Meng X, Chen J, Guan X, He Y, Pan C, Zheng XS, Lu X, Chen S, Huang W. Exome sequencing reveals the genetic landscape and frequent inactivation of PCDHB3 in Chinese rectal cancers. J Pathol. 2018 Mar 14: doi.
5. Qiu L, Tan X, Lin J, Liu RY, Chen S, Geng R, Wu J, Huang W. CDC27 Induces Metastasis and Invasion in Colorectal Cancer via the Promotion of Epithelial-To-Mesenchymal Transition. J Cancer. 2017 Aug 21;8(13):2626-2635.
6. Wu J, Tan X, Lin J, Yuan L, Chen J, Qiu L, Huang W. Minicircle-oriP-miR-31 as a Novel EBNA1-Specific miRNA Therapy Approach for Nasopharyngeal Carcinoma. Hum Gene Ther. 2017 May;28(5):415-427.
7. Gao S, Li J, Song L, Wu J, Huang W. Influenza A virus-induced downregulation of miR-26a contributes to reduced IFNα/β production. Virol Sin. 2017 Aug;32(4):261-270.
8. Lin J, Tan X, Qiu L, Huang L, Zhou Y, Pan Z, Liu R, Chen S, Geng R, Wu J, Huang W. Long Noncoding RNA BC032913 as a Novel Therapeutic Target for Colorectal Cancer that Suppresses Metastasis by Upregulating TIMP3. Mol Ther Nucleic Acids. 2017 Sep 15;8:469-481.
9. Shi W, Ye Z, Zhuang L, Li Y, Shuai W, Zuo Z, Mao X, Liu R, Wu J, Chen S,Huang W. Olfactomedin 1 negatively regulates NF-κB signalling and suppresses the growth and metastasis of colorectal cancer cells. J Pathol. 2016 Nov;240(3):352-365.
10. Yao C, Sheng C, Liu D, Gao S, Jiang W, Yu H, Li J, Chen H, Wu J, Pan C, Chen S, Huang W. [Expression, purification of recombinant human cryptochrome I and its application in preparation of protective agent for radiotherapy]. Sheng Wu Gong Cheng Xue Bao. 2015 Jan;31(1):135-46.
11. Wang L, Xu Y, Luo C, Sun J, Zhang J, Lee MW, Bai A, Chen G, Frenz CM, Li Z, Huang W. MAGEA10 gene expression in non-small cell lung cancer and A549 cells, and the affinity of epitopes with the complex of HLA-A 0201 alleles. Cell Immunol. 2015 Sep;297(1):10-8.
12. Liu D, Sheng C, Gao S, Yao C, Li J, Jiang W, Chen H, Wu J, Pan C, Chen S,Huang W. SOCS3 Drives Proteasomal Degradation of TBK1 and Negatively Regulates Antiviral Innate Immunity. Mol Cell Biol. 2015 Jul;35(14):2400-13.
13. Liu J, Wu J, Zhou L, Pan C, Zhou Y, Du W, Chen JM, Zhu X, Shen J, Chen S, Liu RY, Huang W. ZD6474, a new treatment strategy for human osteosarcoma, and its potential synergistic effect with celecoxib. Oncotarget. 2015 Aug 28;6(25):21341-52.
14. Chen H, Gao S, Li J, Liu D, Sheng C, Yao C, Jiang W, Wu J, Chen S, Huang W.Wedelolactone disrupts the interaction of EZH2-EED complex and inhibits PRC2-dependent cancer. Oncotarget. 2015 May 30;6(15):13049-59.
15. Gao S, Wu J, Liu RY, Li J, Song L, Teng Y, Sheng C, Liu D, Yao C, Chen H,Jiang W, Chen S, Huang W. Interaction of NS2 with AIMP2 facilitates the switch from ubiquitination to SUMOylation of M1 in influenza A virus-infected cells. J Virol. 2015 Jan;89(1):300-11.
16. Li J, Song L, Zhou L, Wu J, Sheng C, Chen H, Liu Y, Gao S, Huang W. A MicroRNA Signature in Gestational Diabetes Mellitus Associated with Risk of Macrosomia. Cell Physiol Biochem. 2015;37(1):243-52.
17. Wu Q, Huang W. [Producing Ad-IFN gamma by suspension culture of HEK293 cells in a disposable bioreactor]. Sheng Wu Gong Cheng Xue Bao. 2014 Nov;30(11):1786-90.
18. KatsuyukiHamada,ToshiroShirakawa服務為一體,ShujiTerao問題,AkinobuGotoh,KenzaburoTani全會精神,HuangW. Biosafety studies of carrier cells infected with a replication-competent adenovirus introduced by IAI 3B promoter. Mol Ther Methods Clin Dev. 2014 May 28;1:14019.
19. Liu D, Sheng C, Gao S, Jiang W, Li J, Yao C, Chen H, Wu J, Chen S, Huang W. eEF1Bγ is a positive regulator of NF-кB signaling pathway. Biochem Biophys Res Commun. 2014 Apr 4;446(2):523-8.
20. Ye W, Liu R, Pan C, Jiang W, Zhang L, Guan Z, Wu J, Ying X, Li L, Li S, Tan W, Zeng M, Kang T, Liu Q, Thomas GR, Huang M, Deng W, Huang W. Multicenter randomized phase 2 clinical trial of a recombinant human endostatin adenovirus in patients with advanced head and neck carcinoma. Mol Ther. 2014 Jun;22(6):1221-1229.
21. Wang L, Gao S, Jiang W, Luo C, Xu M, Bohlin L, Rosendahl M, Huang W. Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration. Int J Mol Sci. 2014 Sep 15;15(9):16226-45.
22. Zhou Y, Wu J, Fu X, Du W, Zhou L, Meng X, Yu H, Lin J, Ye W, Liu J, Peng H, Liu RY, Pan C, Huang W. OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer. Mol Cancer. 2014 Nov 28;13:258.
23. Yu H, Ye W, Wu J, Meng X, Liu RY, Ying X, Zhou Y, Wang H, Pan C, Huang W. Overexpression of sirt7 exhibits oncogenic property and serves as a prognostic factor in colorectal cancer. Clin Cancer Res. 2014 Jul 1;20(13):3434-45.
24. Liu RY, Peng JL, Li YQ, Huang BJ, Lin HX, Zhou L, Luo HL, Huang W.Tumor-specific cytolysis caused by an E1B55K-attenuated adenovirus in nasopharyngeal carcinoma is augmented by cisplatin. Anat Rec (Hoboken). 2013Dec;296(12):1833-41.
25. Xie FJ, Zhao P, Zhang YP, Liu FY, Nie XL, Zhu YH, Yu XM, Zheng QQ, Mao WM,Lu HY, Wei H, Huang W. Adenovirus-mediated interferon-γ gene therapy induced human pancreatic carcinoma Capan-2 cell apoptosis in vitro and in vivo. Anat Rec (Hoboken). 2013 Apr;296(4):604-10.
26. Ying X, Wu J, Meng X, Zuo Y, Xia Q, Chen J, Feng Y, Liu R, Li L, Huang W. AC133 expression associated with poor prognosis in stage II colorectal cancer. Med Oncol. 2013 Mar;30(1):356.
27. Li LX, Zhang YL, Zhou L, Ke ML, Chen JM, Fu X, Ye CL, Wu JX, Liu RY, Huang W.Antitumor efficacy of a recombinant adenovirus encoding endostatin combined with an E1B55KD-deficient adenovirus in gastric cancer cells. J Transl Med. 2013 Oct 14;11:257.
28. Chen S, Sheng C, Liu D, Yao C, Gao S, Song L, Jiang W, Li J, Huang W. Enhancer of zeste homolog 2 is a negative regulator of mitochondria-mediated innate immune responses. J Immunol. 2013 Sep 1;191(5):2614-23.
29. Yu H, Meng X, Wu J, Pan C, Ying X, Zhou Y, Liu R, Huang W. Cryptochrome 1 overexpression correlates with tumor progression and poor prognosis in patients with colorectal cancer. PLoS One. 2013 Apr 23;8(4):e61679.
30. Jiang W, Wang Q, Chen S, Gao S, Song L, Liu P, Huang W. Influenza A virus NS1 induces G0/G1 cell cycle arrest by inhibiting the expression and activity of RhoA protein. J Virol. 2013 Mar;87(6):3039-52.
31. Meng X, Wu J, Pan C, Wang H, Ying X, Zhou Y, Yu H, Zuo Y, Pan Z, Liu RY, Huang W. Genetic and epigenetic down-regulation of microRNA-212 promotes colorectal tumor metastasis via dysregulation of MnSOD. Gastroenterology. 2013 Aug;145(2):426-36.
32. Liu RY, Zhu YH, Zhou L, Zhao P, Li HL, Zhu LC, Han HY, Lin HX, Kang L, Wu JX, Huang W. Adenovirus-mediated delivery of interferon-γ gene inhibits the growth of nasopharyngeal carcinoma. J Transl Med. 2012 Dec 28;10:256.
33. Wang Q, Chen Y, Gao S, Jiang W, Song L, Huang W. [Immunological efficiency induced by HIV-1 p24 DNA combined with P24 protein]. Sheng Wu Gong Cheng Xue Bao. 2011 May;27(5):773-80.
34. Zuo Y, Wu J, Xu Z, Yang S, Yan H, Tan L, Meng X, Ying X, Liu R, Kang T,Huang W. Minicircle-oriP-IFNγ a novel targeted gene therapeutic system for EBV positive human nasopharyngeal carcinoma. PLoS One. 2011 May 5;6(5):e19407.
35. Song L, Gao S, Jiang W, Chen S, Liu Y, Zhou L, Huang W. Silencing suppressors viral weapons for countering host cell defenses. Protein Cell. 2011 Apr;2(4):273-81.
36. Wang H, Wu J, Meng X, Ying X, Zuo Y, Liu R, Pan Z, Kang T, Huang W. MicroRNA-342 inhibits colorectal cancer cell proliferation and invasion by directly targeting DNA methyltransferase 1. Carcinogenesis. 2011 Jul;32(7):1033-42.
37. Zhang C, Liu H, Gao S, Huang W, Wang Z. [Polyethylenimine and minicircle DNA based gene transfer]. Sheng Wu Gong Cheng Xue Bao. 2010 Jun;26(6):772-9.
38. Tan L, Xu B, Liu R, Liu H, Tan H, Huang W. Gene therapy for acute myeloid leukemia using Sindbis vectors expressing a fusogenic membrane glycoprotein. Cancer Biol Ther. 2010 Mar 1;9(5):350-7.
39. Zhao P, Luo R, Wu J, Xie F, Li H, Xiao X, Fu L, Zhu X, Liu R, Zhu Y, Liang Z, Huang W. E10A, an adenovirus carrying human endostatin gene, in combination with docetaxel treatment inhibits prostate cancer growth and metastases. J Cell Mol Med. 2010 Jan;14(1-2):381-91.
40. Liu H, Song L, Huang W. [MiR26a and miR939 regulate the replication of H1N1 influenza virus in MDCK cell]. Wei Sheng Wu Xue Bao. 2010 Oct;50(10):1399-405.
41. Han H, Zhong C, Zhang X, Liu R, Pan M, Tan L, Li Y, Wu J, Zhu Y, Huang W. Genistein induces growth inhibition and G2/M arrest in nasopharyngeal carcinoma cells. Nutr Cancer. 2010;62(5):641-7.
42. Zhang C, Gao S, Jiang W, Lin S, Du F, Li Z, Huang W. Targeted minicircle DNA delivery using folate-poly(ethylene glycol)-polyethylenimine as non-viral carrier. Biomaterials. 2010 Aug;31(23):6075-86.
43. Yan H, Wu J, Liu W, Zuo Y, Chen S, Zhang S, Zeng M, Huang W. MicroRNA-20a overexpression inhibited proliferation and metastasis of pancreatic carcinoma cells. Hum Gene Ther. 2010 Dec;21(12):1723-34.
44. Song L, Liu H, Gao S, Jiang W, Huang W. Cellular microRNAs inhibit replication of the H1N1 influenza A virus in infected cells. J Virol. 2010 Sep;84(17):8849-60.
45. Wu J, Xiao X, Jia H, Chen J, Zhu Y, Zhao P, Lin H, Huang W. Dynamic distribution and expression in vivo of the human interferon gamma gene delivered by adenoviral vector. BMC Cancer. 2009 Feb 16;9:55.
46. Zhang Y, Zhang Y, Guo S, Huang W. Tyrosine kinase inhibitor loaded PCL microspheres prepared by S/O/W technique using ethanol as pretreatment agent. Int J Pharm. 2009 Mar 18;369(1-2):19-23.
47. Tan L, Jia H, Liu R, Wu J, Han H, Zuo Y, Yang S, Huang W. Inhibition of NF-kappaB in fusogenic membrane glycoprotein causing HL-60 cell death implications for acute myeloid leukemia. Cancer Lett. 2009 Jan 8;273(1):114-21.
48. Jia HY, Wu JX, Zhu XF, Chen JM, Yang SP, Yan HJ, Tan L, Zeng YX, Huang W.ZD6474 inhibits Src kinase leading to apoptosis of imatinib-resistant K562 cells. Leuk Res. 2009 Nov;33(11):1512-9.
49. Li Y, Shao JY, Liu RY, Zhou L, Chai LP, Li HL, Han HY, Huang BJ, Zeng MS,Zhu XF, Liu Q, Fu LW, Huang W. Evaluation of long-term toxicity of Ad/hIFN-, an Adenoviral vector encoding the human interferon-gamma gene, in nonhuman primates.Hum Gene Ther. 2008 Aug;19(8):827-39.
50. Xue G, Liu RY, Li Y, Cheng Y, Liang ZH, Wu JX, Zeng MS, Tian FZ, Huang W. Dendritic cells modified with 6Ckine/IFNgamma fusion gene induce specific cytotoxic T lymphocytes in vitro. Cancer Immunol Immunother. 2007 Nov;56(11):1831-43.
51. Huang BJ, Liu RY, Huang JL, Liang ZH, Gao GF, Wu JX, Huang W. Long-Term toxicity studies in Canine of E10A, an adenoviral vector for human endostatin gene. Hum Gene Ther. 2007 Mar;18(3):207-21.
52. Zhao P, Zhu YH, Wu JX, Liu RY, Zhu XY, Xiao X, Li HL, Huang BJ, Xie FJ, Chen JM, Ke ML, Huang W. Adenovirus-mediated delivery of human IFNgamma gene inhibits prostate cancer growth. Life Sci. 2007 Aug 9;81(9):695-701.
53. Huang J, Wang F, Argyris E, Chen K, Liang Z, Tian H, Huang W, Squires K, Verlinghieri G, Zhang H. Cellular microRNAs contribute to HIV-1 latency in resting primary CD4+ T lymphocytes. Nat Med. 2007 Oct;13(10):1241-7.
54. Li L, Liu RY, Huang JL, Liu QC, Li Y, Wu PH, Zeng YX, Huang W. Adenovirus-mediated intra-tumoral delivery of the human endostatin gene inhibits tumor growth in nasopharyngeal carcinoma. Int J Cancer. 2006 Apr 15;118(8):2064-71.
55. Wu J, Xiao X, Zhao P, Xue G, Zhu Y, Zhu X, Zheng L, Zeng Y, Huang W. Minicircle-IFNgamma induces antiproliferative and antitumoral effects in human nasopharyngeal carcinoma. Clin Cancer Res. 2006 Aug 1;12(15):4702-13.
56. Huang JL, Huang J, Duan ZH, Wei J, Min J, Luo XH, Li JG, Tan WP, Wu LZ, Liu RY, Li Y, Shao J, Huang BJ, Zeng YX, Huang W. Th2 predominance and CD8+ memory T cell depletion in patients with severe acute respiratory syndrome. Microbes Infect. 2005 Mar;7(3):427-36.
57. He GA, Xue G, Xiao L, Wu JX, Xu BL, Huang JL, Liang ZH, Xiao X, Huang BJ, Liu RY, Huang W. Dynamic distribution and expression in vivo of human endostatin gene delivered by adenoviral vector. Life Sci. 2005 Aug 5;77(12):1331-40.
58. Liu RY, Wu LZ, Huang BJ, Huang JL, Zhang YL, Ke ML, Wang JM, Tan WP, Zhang RH, Chen HK, Zeng YX, Huang W. Adenoviral expression of a truncated S1 subunit of SARS-CoV spike protein results in specific humoral immune responses against SARS-CoV in rats. Virus Res. 2005 Sep;112(1-2):24-31.
59. Huang W, Flint SJ. Unusual properties of adenovirus E2E transcription by RNA polymerase III. J Virol. 2003 Apr;77(7):4015-24.
60. Huang W, Todaro L, Francesconi LC, Polenova T. 51V magic angle spinning NMR spectroscopy of six-coordinate Lindqvist oxoanions a sensitive probe for the electronic environment in vanadium-containing polyoxometalates Counterions dictate the 51V fine structure constants in polyoxometalate solids. J Am Chem Soc. 2003 May 14;125(19):5928-38.